Abstract
Single-Walled Carbon Nanotubes (SWCNTs) are widely used as potential carriers in drug delivery systems. The objective of this work was to observe the effects of pristine, and single-stranded DNA oligonucleotide functionalized SWCNT over the locomotion pattern in the nematode model, Caenorhabditis elegans. The implication of ssDNA in the as-modified SWCNT has been understood in terms of lowering the toxic effects of the pristine SWCNT and thereby normalizing the altered navigation pattern of the worms. Chemotaxis assay displayed an increased migration of the worms towards pristine and ssDNA functionalized SWCNT in comparison to ultrapure water as control. Additionally, paralytic movement was observed with SWCNT exposure in contrast to ssDNA-functionalized SWCNT-exposed animals. High doses of pristine SWCNT further displayed an increased expression of specific proteins obtained from the total protein extracts of the animals. Thus, the alteration in the navigation pattern of the worms, treated with pristine SWCNT, might be ascribed as a result of differentially expressed muscle proteins. Moreover, it is interesting to note that the modified SWCNT was effective in alleviating the atypical form of the inherent movements of the worm. Future investigation will further reveal the protein targets responsible for the altered navigation pattern of the worms.
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