Abstract
Parental reovirus is not completely uncoated after infection to yield free genome RNA. Instead it is converted into a subviral particle which contains besides 10 segments of double-stranded RNA and A-rich RNA, all core polypeptides namely λ1, λ2, μ1, and σ2 and a polypeptide with a molecular weight of 65,000 which is derived from the outer capsomere protein μ2 by cleavage. Isolated partially uncoated particles catalyze the synthesis of virus specific messenger RNA. Late during the replication cycle partially uncoated particles are converted into particles with a slightly higher density in CsCl than the virus by the addition of newly synthesized polypeptide σ3.
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