Abstract
The dose-response relationship for neutron irradiation of a quantitative in vivo mouse tumor cell system was determined and compared with the dose- response relationship for x irradiation performed under both anoxic and oxygenated conditions. Values of n = l.0 and D/sub 37/. = 85 rads were obtained for fission-spectrum fast neutron irradiation as compared with n = 1.6 and D/sub 37/ = 365 rads for x irradiation under anoxic conditions and n = l.6 and D/su b 37/ = I60 rads for x irradiation under oxygenated conditions. The cell system employed conforms in its radiobiological behavior with other mammalian cell culture systems and constitutes a useful test system for the study of cell radiobiological phenomena. The same or greater degree of apparent radiosensitivity was attained by direct neutron irradiation of cells in the anoxic state as was attained by x irradiation in the oxygenated state. Radiosensitivity cannot be defined in terms of a single RBE ratio but only in terms of the complete dose-response relationship or in respect to the parameters, n and D/sub 37/, which describe this relationship, (auth)
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