Abstract
The reactivity of [Pt( l -Met- S , N ) 2 ] (PtM 2 ), a key metabolite of cisplatin, towards biological thiols glutathione (GSH) and l -cysteine ( l -Cys) was investigated by HPLC, ESMS and 1 H NMR techniques. The cis -isomer of PtM 2 was found more reactive than the trans -isomer. The S , N -chelated l -methionine ( l -MetH) can be readily displaced by both GSH and l -Cys, giving rise to the formation of thiolate-bridged polynuclear Pt(II) adducts. The substitution rate and the polymerization extent are highly dependent on pH values of the reaction solution.
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