Abstract
BackgroundThe association between family history and risk of triple negative breast cancer and ductal carcinoma in situ (DCIS) has not been well investigated, especially in Asian populations. We investigated the association between family history and risk of DCIS or triple negative breast cancer in a Han Chinese population.MethodsA case–control study, comprising 926 breast cancer patients and 1,187 benign breast disease controls, was conducted in our hospital. Multivariate logistic regression was used to assess the relationships between family history and risk of DCIS or triple negative breast cancer.ResultsSubjects with a family history of breast cancer had higher breast cancer risk than those without a family history (odds ratio (OR) = 2.11, 95% confidence interval (CI) = 1.26 to 3.52). Family history was not significantly associated with an increased risk of DCIS (OR = 1.27, 95% CI = 0.36 to 4.46), while family history was significantly associated with an increased risk of invasive breast cancer (OR = 2.22, 95% CI = 1.32 to 3.75), irrespective of triple negative breast cancer (OR = 3.35, 95% CI = 1.43 to 7.88) or non-triple negative breast cancer (OR = 2.14, 95% CI = 1.21 to 3.80).ConclusionOur results indicate that having a family history of breast cancer is associated with an increased risk of triple negative breast cancer with a magnitude of association similar to that for non-triple negative breast cancer. Furthermore, family history is not significantly associated with an increased risk of DCIS. Future cohort studies with larger sample sizes are still needed to explore these relationships.
Highlights
The association between family history and risk of triple negative breast cancer and ductal carcinoma in situ (DCIS) has not been well investigated, especially in Asian populations
The aim of this study was to investigate the association between family history and risk of DCIS or triple negative breast cancer in a Han Chinese population
More patients in the case group had two or more children (30.6%) than in the control group (19.4%) (P < 0.001); this was in accordance with the age distribution between the two groups
Summary
The association between family history and risk of triple negative breast cancer and ductal carcinoma in situ (DCIS) has not been well investigated, especially in Asian populations. We investigated the association between family history and risk of DCIS or triple negative breast cancer in a Han Chinese population. A special subgroup of patients is associated with aggressive clinical behavior and poor outcome [4,5,6] This subgroup of breast cancer is characterized by absent expression of estrogen receptor (ER), progesterone receptor (PR) and HER2 receptor and is defined as triple negative breast cancer. The association between family history and risk of triple negative breast cancer has not been well investigated. The relationship between family history and risk of triple negative breast cancer is still not clear
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