Abstract
Several GWASs and epidemiological studies (Alikhan et al., 2011; Shen et al., 2016; Spritz, 2012; Spritz and Andersen, 2017) have regarded genetic factors to play a significant role in the etiology of vitiligo. Previous familial studies (Alkhateeb et al., 2003; Deo and Ganjre, 2018; Majumder et al., 1993; Narita et al., 2011; Onunu and Kubeyinje, 2003; Xiukun Sun et al., 2006) have reported an elevated risk of disease in biological relatives of patients as compared with the general population. However, the magnitude of risk reported by these studies ranges widely, which may be attributable to sample size and heterogeneous study designs.
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