Abstract
Although a viral etiology has been suggested for recurrent aphthous stomatitis, 1 most investigators have not been able to isolate a virus from recurrent aphthous lesions. 2 Some investigators, however, have reported that patients with recurrent aphthous stomatitis were benefited by vaccination with smallpox vaccine 3 and particularly by the use of intradermal injections of smallpox vaccine. 4 This study was attempted in an effort to corroborate the latter positive findings. Each patient presented had a history of recurrent aphthous stomatitis of at least one year's duration (many much longer) and had been observed by us for a prolonged period during the course of placebo and other unsuccessful therapy, some phases of which have already been reported. 5 In no case was any evidence of accompanying skin lesions noted. METHODS Five intradermal injections of smallpox vaccine were administered to each of the 12 patients (four men and eight women,
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