Abstract
It was demonstrated that parenteral administration of L-Triiodothyronine (L-T3) initially increased and then decreased utilization of glucose by the RBC of rabbits(1). Because of this fact, we became interested in studying the effects of clinically large doses of this compound on utilization of glucose by the human erythrocytes. Certainly, if a peripheral cellular effect could be demonstrated, then there would be a possibility of establishing a clinically useful tool for reflecting total body metabolism and perhaps evaluating thyroid function. The present investigation was therefore designed to study in humans: 1) normal fluctuations in rate of glucose utilization by RBC, and 2) effect of L-T3 on this rate.Methods and material. Fasting venous blood was obtained from healthy volunteer men and women to insure satisfactory range in age and sex distribution. These individuals were clinically free of any disease and not taking medication. The laboratory procedure followed has been described(1). Blood samples w...
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