Abstract
The distribution of two aminoglycosides and three penicillins was studied in dogs. Serial samples of interstitial tissue fluid were obtained from subcutaneous silicone rubber capsules and compared with simultaneous serum samples. The results showed the reproducibility of the method both between animals and between experiments. Tobramycin showed a trend to higher serum and tissue fluid concentrations compared to gentamicin but these differences were not statistically significant. The striking differences between the tissue fluid concentrations of ampicillin and cloxacillin were related to the high protein binding of the latter. It is concluded that an adequate tissue fluid concentration requires an adequately maintained serum concentration; drugs that are rapidly excreted and especially those that are highly protein bound, should be given in doses sufficient to produce such a serum concentration.
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