Factors Correlated with Post Endoscopic Retrograde Cholangiopancreatography Hyperamylasemia: A Single Center Study

Abstract

Background and aim of the work: Identifying patient at risk for post ERCP hyperamylasemia which may progress to pancreatitis is essential to minimize morbidity and mortality by suitable procedural or pharmacological intervention. In this study hyperamylasemia following ERCP were recorded and correlated with different patient or procedure related risk factors. Patients and methods: The data of all patients who met the inclusion criteria of the study and underwent endoscopic retrograde cholangiopancreatography (ERCP) in Al-Hada Armed Force Hospital, Taif, Saudi Arabia from January 2015 to March 2016, were collected through a review of their hospital and data base records. Results: There were 138 patients (86 females and 52 males) with mean age of 63.7±15.3 years. Hyperamylasemia was developed in 29.7% of them; 16.8% were recorded as asymptomatic hyperamylasemia and post ERCP pancreatitis in the remaining 13%. Multivariate analysis confirmed that, the gender, precut sphincterotomy and pancreatic duct cannulation were significant risk factors for development of non symptomatic hyperamylasemia and confirmed also the significance of precut sphincterotomy and pancreatic duct cannulation for post ERCP pancreatitis. Conclusion: This study confirmed the correlation of precut sphincterotomy and pancreatic duct cannulation with post ERCP hyperamylasemia and pancreatitis and in such conditions preventive measures are recommended.