Facilitative effects of use-dependent learning on interlimb transfer of visuomotor adaptation in a person with congenital mirror movements.

Abstract

It has been shown that use-dependent learning can facilitate interlimb transfer of motor learning in neurologically intact individuals. However, it is unknown whether it can also facilitate interlimb transfer in individuals with neurological impairment. In this case study, we examined the effect of use-dependent learning on interlimb transfer of visuomotor adaptation in a person with congenital mirror movements, DB, who showed no interlimb transfer in our previous studies (Bao, Morgan, Lei, & Wang, 2020; Javidialsaadi, & Wang, 2021). DB first performed reaching movements with the right arm repeatedly while adapting to a visuomotor rotation condition with the left arm (training session), and then adapted to the same rotation condition with the right arm (transfer session). DB's right arm performance in the transfer session was significantly better than that observed in our previous studies, indicating interlimb transfer of visuomotor adaptation. The percentage of transfer was over 90%, which is similar to that observed in healthy young adults previously. These findings suggest that interlimb transfer of visuomotor adaptation can occur by involving model-based learning, which is effector independent, and/or use-dependent (or model-free) learning, which is effector specific; and also that the relative contribution of use-dependent learning to interlimb transfer of visuomotor adaptation can be as large as that of model-based learning.