Abstract
Rats with electrolytic lesions of the midbrain raphe, sham lesions, or nonmanipulated controls were trained on a discriminated Y-maze active-avoidance task. Subsequent to avoidance training all subjects were sacrificed and forebrain concentrations of serotonin were measured. It was found that raphe lesions greatly enhanced acquisition of the avoidance response and significantly decreased forebrain serotonin levels. Measures of motor activity recorded in addition to the avoidance response indicated that raphe lesions attenuated the behavioral suppression or “freezing”, typically observed following shock, producing a behavioral baseline more compatible with acquiring the avoidance response.
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