Abstract
Donation after circulatory death (DCD) is a promising solution for increasing cardiac graft availability, but concerns persist due to ischemia/reperfusion injury (IRI). Using an isolated rat heart model of DCD, we identified three reperfusion strategies that significantly improve post-ischemic contractile recovery1: mild hypothermia (MH), mechanical post-conditioning (MPC) and hypoxia (HY). Given the key role of mitochondria in IRI, we hypothesized that mitochondrial changes contribute to these cardioprotective strategies.
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