Abstract
The transfer of four β-adrenoceptor blocking agents of different lipophilicity across an artificial lipid membrane was measured using the rotating diffusion cells (RDC). A facilitated transport mechanism was established when oleic acid and lauric acid were incorporated in the membrane, using an appropriate pH gradient. The diffusion of metoprolol, oxprenolol and to a lesser extent propranolol was enhanced by an ion-pair mechanism in the presence of the fatty acids. The transfer of atenolol, the most hydrophilic of the drugs under investigation, was not enhanced. The results are useful in understanding the way in which charged molecules may be transported across biological membranes by ion pair mechanisms and also for the development of solid supported liquid membranes in separation technology.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.