Abstract
The transfer of four β-adrenoceptor blocking agents of different lipophilicity across an artificial lipid membrane was measured using the rotating diffusion cells (RDC). A facilitated transport mechanism was established when oleic acid and lauric acid were incorporated in the membrane, using an appropriate pH gradient. The diffusion of metoprolol, oxprenolol and to a lesser extent propranolol was enhanced by an ion-pair mechanism in the presence of the fatty acids. The transfer of atenolol, the most hydrophilic of the drugs under investigation, was not enhanced. The results are useful in understanding the way in which charged molecules may be transported across biological membranes by ion pair mechanisms and also for the development of solid supported liquid membranes in separation technology.
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