Talanta | VOL. 253
Read

Facile synthesis of Cu2+-immobilized magnetic covalent organic frameworks for highly efficient enrichment and sensitive determination of five phthalate monoesters from mouse plasma with HPLC-MS/MS

Publication Date Feb 1, 2023

Abstract

Development of a simple, highly selective, and sensitive analytical method for phthalate monoesters (mPAEs) remains a challenge due to the complexity of biological samples. To address this issue, Cu2+ immobilized magnetic covalent organic frameworks (Fe3O4@TtDt@Cu2+ composites) with core-shell structures were prepared to enhance the enrichment efficiency of mPAEs by a facile approach synthesis of COFs shells with inherent bifunctional groups on Fe3O4 NPs and further Cu2+ immobilization. The composites exhibit high specific surface area (348.1m2g-1), outstanding saturation magnetization (34.94 emu g-1), ordered mesoporous structure, Cu2+ immobilization, and excellent thermal stability. Accordingly, a magnetic solid-phase extraction (MSPE) pretreatment technique based on Cu2+ immobilized COF composites combined with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established, and key parameters including the adsorbent amount, adsorption time, elution solvent, etc. were examined in detail. The developed analytical method showed wide linear ranges (10-8000ngL-1), low limit of detections (LODs, 2-10ngL-1), and good correlation coefficients (R2≥0.9904) for the five mPAEs. Furthermore, the analytical method was also successfully applied to the highly sensitive detection of metabolite mPAEs in mouse plasma samples, indicating the promising application of the Fe3O4@TtDt@Cu2+ composites as a quick and efficient adsorbent in the sample pretreatment.

Concepts

Mouse Plasma Samples Phthalate Monoesters Magnetic Solid-phase Extraction Fe3O4 NPs High-performance Liquid Chromatography-tandem Mass Spectrometry Excellent Thermal Stability Low Limit Of Detections Elution Solvent Mouse Plasma Adsorption Time

Round-ups are the summaries of handpicked papers around trending topics published every week. These would enable you to scan through a collection of papers and decide if the paper is relevant to you before actually investing time into reading it.

Coronavirus Research Articles published between Nov 28, 2022 to Dec 04, 2022

R DiscoveryDec 05, 2022
R DiscoveryArticles Included:  5

The coronavirus disease 2019 (COVID-19) is a contagious disease that is caused by a novel coronavirus. Bentham is offering subject-based scholarly con...

Read More

Climate change Research Articles published between Nov 28, 2022 to Dec 04, 2022

R DiscoveryDec 05, 2022
R DiscoveryArticles Included:  5

We use cookies to improve your website experience. To learn about our use of cookies and how you can manage your cookie settings, please see our Cooki...

Read More

Quality Of Education Research Articles published between Nov 28, 2022 to Dec 04, 2022

R DiscoveryDec 05, 2022
R DiscoveryArticles Included:  4

Introduction: The Internet is an extensively used source of medical education by the public. YouTube is a valuable source of information which can be ...

Read More

Gender Equality Research Articles published between Nov 28, 2022 to Dec 04, 2022

R DiscoveryDec 05, 2022
R DiscoveryArticles Included:  3

Gender equity in the classroom is important for teachers to think about in order to ensure they are creating safe environments that allow their studen...

Read More

Coronavirus Pandemic

You can also read COVID related content on R COVID-19

R ProductsCOVID-19

ONE PROBLEM . ONE PURPOSE . ONE PLACE

Creating the world’s largest AI-driven & human-curated collection of research, news, expert recommendations and educational resources on COVID-19

COVID-19 Dashboard

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on “as is” basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The Copyright Law.