Abstract
A convergent synthetic approach is presented for the straightforward synthesis of the tetrasaccharide fragment of the capsular polysaccharide of Streptococcus pneumoniae type 15B. Coupling of a disaccharide thioglycoside donor with a disaccharide acceptor furnished the required tetrasaccharide in excellent yield.
Highlights
Infections due to Streptococcus pneumoniae remain one of the major concerns in the developed and developing countries.[1]
A capsular polysaccharide (CPS) based vaccine against streptococcal infection has been used for a long time.[3]
These capsular polysaccharides (CPSs) have been isolated from the natural sources, earlier studies showed that synthetic neoglycoconjugates derived from smaller oligosaccharide fragments of the capsular polysaccharide can generate sufficient protective immune response after conjugation with proteins.[4]
Summary
Infections due to Streptococcus pneumoniae remain one of the major concerns in the developed and developing countries.[1].
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