Facile Synthesis of (2S,1′S,2′S)-2-(Carboxycyclopropyl)glycine, an Isotype-Selective Agonist of Metabotropic Glutamate Receptors

Dawei Ma,Zhaochun Ma

doi:10.1016/s0040-4039(97)10037-5

Facile Synthesis of (2S,1′S,2′S)-2-(Carboxycyclopropyl)glycine, an Isotype-Selective Agonist of Metabotropic Glutamate Receptors

Dawei Ma, Zhaochun Ma

https://doi.org/10.1016/s0040-4039(97)10037-5

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Journal: Tetrahedron Letters	Publication Date: Oct 1, 1997
Citations: 25

Affiliation: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

#Sharpless's Asymmetric Dihydroxylation Reaction #Asymmetric Dihydroxylation Reaction + Show 4 more

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Abstract

(2S,1′S,2′S)-2-(Carboxycyclopropyl)glycine (L-CCG-I) was synthesized in 12 steps and 14% overall yield by using Sharpless's asymmetric dihydroxylation reaction and stereochemically controlled cyclopropanation as key steps. © 1997 Elsevier Science Ltd.

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