Abstract
A facile biofouling-resistant surface coating was developed based on catechol-conjugated poly(N-vinylpyrrolidone) (CA-PVP). CA-PVP can be securely and effectively coated on glass, gold, and tissue culture polystyrene (TCPS) surfaces under a mild condition as characterized by ATR-FTIR and PVP-complexation with iodine and hydrogen peroxide. PVP itself without catechol conjugation, on the other hand, cannot achieve well-coating on surfaces. The coated surfaces became more hydrophilic and protein-resistant due to the presence of PVP as measured by the reduced contact angles and surface plasmon resonance (SPR) responses. The significantly enhanced protein resistance created by CA-PVP coatings leads to its significant anti-biofilm and fibroblast cell adhesion resistance as observed by fluorescent microscope. CA-PVP coating also demonstrated its high biocompatibility that ≥ 95% cell viability of mouse fibroblast cells still can be maintained after 48 h cultivation.
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