Facile fabrication of silicon coating for improving biodegradation and cytocompatibility of pure magnesium by hydrothermal method

Abstract

In this study, a bioactive silicon coating was fabricated for reducing the degradation rate and enhancing the cytocompatibility of the pure magnesium. The morphology and phase of coating were characterized by a scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffractometer (XRD), and X-ray photoelectron spectroscopy (XPS), respectively. The electrochemical and immersion tests were conducted in a simulated body fluid to evaluate the in vitro degradation behavior of the Si-coated sample. Cell viability and cell adhesion assays of human osteosarcoma cells were performed to determine the biocompatibility of the Si-coating. The XRD pattern suggested that MgO, Mg2SiO4 and SiO2 were formed on the Si-coated sample. The results of the electrochemical and immersion tests showed that the Si-coating could significantly decrease degradation rate of the pure magnesium. Meanwhile, the Si-coating could significantly promote the cell adhesion, migration and proliferation in vitro. It is considered that the Si-coating showed a promising application in improving the anticorrosion and biocompatibility of the pure magnesium.