Abstract
Given the pivotal role of hydrogen peroxide (H2O2) in numerous biological progresses, there has been a recent surge in the development of highly effective electrochemical sensors for H2O2 detection. In this article, we propose an enzyme-free amperometric system for the sensitive and selective recognition of H2O2, leveraging ultrafine PtPd alloy/ionic liquid-carbon dots (IL-CDs) nanocomposites modified flexible carbon fiber. The IL-CDs were synthesized through the direct electrodeposition of ionic liquid [BMIM][PF6] using Pt sheets as electrodes. Subsequently, a sequential electrodeposition of IL-CDs, H2PtCl6, and PdCl2 onto the activated carbon fiber (ACF) yielded the PtPd/IL-CDs/ACF microelectrode. This microelectrode serves as an enzyme-free amperometric sensor for H2O2 detection, exhibiting an improved response with a significantly lower detection limit of 0.29 μM and a relatively broad linear range spanning from 2 to 6561 μM. Furthermore, this enzyme-free amperometric H2O2 sensor demonstrates remarkable stability over extended periods and exceptional performance in practical applications, such as the analysis of commercially available milk, human serum, human urine, and living cancer cells analysis. This study offers a fresh perspective on amperometric sensors based on metal alloys and CDs electrode, highlighting the potential of enzyme-independent detection for hydrogen peroxide in biological systems.
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