Abstract
This paper describes the use of a printed circuit technology to generate hydrophilic channels in a filter paper. Patterns of channels were designed using Protel soft, and printed on a blank paper. Then, the patterns were transferred to a sheet copper using a thermal transfer printer. The sheet copper with patterns was dipped into ferric chloride solution to etch the whole patterns of the sheet copper. At last, the etched sheet copper was coated with a film of paraffin and then a filter paper. An electric iron was used to heat the other side of the sheet copper. The melting paraffin penetrated full thickness of the filter paper and formed a hydrophobic “wall”. Colorimetric assays for the presence of protein and glucose were demonstrated using the paper-based device. The work is helpful to researchers to fabricate paper-based microfluidic devices for monitoring health and detecting disease.
Highlights
Accurate medical diagnosis often calls for quantitative measurements of metabolites, enzymes, and other biomarkers
Paper based microfluidic diagnostic device is an appropriate candidate for such applications
After paraffin had been placed on surface of the sheet copper with channel patterns (Figure 1(e)), a qualitative filter paper was mounted on it (Figure 1(f))
Summary
Accurate medical diagnosis often calls for quantitative measurements of metabolites, enzymes, and other biomarkers. A number of testing devices, such as paper-based indicators and “dip stick” test assays are made of paper.[5,6,7,8] Recently, several methods for fabricating paper-based diagnostic devices have been reported. Martinez and his cooperators[9,10] used paper as a base material to create barrier patterns with photolithographic techniques. The motivation of this work is to present a new method to fabricate paper-based microfluidic device. The major advantage of this novel method over previously reported paper-based microfluidic devices is no using wax printer, plotter, or photolithographic equipment, and the “wall” of the barrier pattern is straight. Several examples of detections for glucose and proteins are presented in this work
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