Abstract
To further optimize the structure of bone tissue engineering composites, silicon nitride nanowires-pyrolytic carbon-hydroxyapatite-carbon matrix (Si3N4nws@PyCnls-HA-C) composites with multilayer core–shell structures are synthesized by chemical vapor deposition (CVD), pulsed electrodeposition (PED), and chemical vapor infiltration (CVI) methods. The microstructure, in-vitro bioactivity, and in-vivo histocompatibility of Si3N4nws@PyCnls-HA-C (SPHC) composites are evaluated. In-vitro, the SPHC exhibited a cell proliferation rate of 157.7% and demonstrated outstanding protein adsorption. In-vivo, the SPHC demonstrated excellent histocompatibility. Therefore, the SPHC composites can serve as an alternative suitable biomaterial for bone tissue engineering.
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