Abstract
Combination therapies are gaining interest, as they are expected to improve the pharmacological effects. However, current drug combination therapies involve the administration of individual drugs together, which results in differences in delivery efficiency to tumor tissues owing to differences in pharmacokinetics. In the present study, we developed heterodimeric nano-prodrugs (NPDs). We designed a heterodimer of podophyllotoxin and SN-38, from which an NPD with a particle size of approximately 50 nm and a high dispersion stability was fabricated. Our findings contribute to the development of next-generation drug delivery systems capable of co-delivering multiple anticancer agents.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
