Abstract
In this research work, three kinds of nonwoven wound dressings were developed from chicken feather keratin (CFK-NW), keratin‑sodium alginate (CFK-SA-NW) and keratin-chitosan (CFK-CS-NW) and characterized using FTIR and SEM. The physical characteristics such as air permeability, thickness and areal density test results revealed the suitability of fabricated materials for wound dressing applications. CFK-SA-NW and CFK-CS-NW indicated a positive antibacterial effect against Gram's positive Staphylococcus aureus and Gram's negative Klebsiella pneumoniae and Escherichia coli bacteria with the zone of inhibition enhanced over >2.0 cm. Moreover, the biomedical potentials of dressing materials has been investigated by cell viability and cytotoxicity tests. Further, the wound healing ability was demonstrated using in vivo model (Albino Wistar rat). The fabricated materials exhibited good support for cell viability and a strong cytocompatibility. Furthermore, the hundred percent wound healing ability of CFK-CS-NW, CFK-SA-NW, CFK-NW and untreated control rats was observed at 15, 17, 21 and 23 days, respectively, Moreover, the wound healing potential of CFK-CS-NW and CFK-SA-NW was found to be better than that of CFK-NW and control group of rats. The outcome of the present study discloses the prospective applications of the developed materials as wound dressing biomaterial.
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