Abstract
Ceftizoxime (C13H12N5NaO5S2) is a parenteral, third-generationcephalosporin antibiotic used to treat bacterial infections including ear, nose, and throat infections. In this work, pectin has been used as a nanocarrier for ceftizoxime due to its high biocompatibility and non-toxicity with tunable surface properties. Ceftizoxime-loaded pectin nanocarriers (CPN) were successfully synthesized by the solvent displacement method. Optimization of nanoformulation was done by response surface methodology using Design-Expert software. The optimized formulation examined various in-vitro characterizations such as particle size, morphology, and FTIR studies. TEM results revealed irregular shape nanoparticles within the range of 29–110 nm. The in-vitro drug release using the dialysis method was performed after 24 h where nanoformulation showed sustained drug release. Drug-loaded nanoparticles revealed good antimicrobial activity against Bacillus cereus, Bacillus polymyxa, Enterobacter aerogenes, and Pseudomonas aeruginosa.
Highlights
The oral drug administration route is very common and convenient for drug delivery [1]
The microorganisms (Bacillus cereus, Bacillus polymyxa, Enterobacter aerogenes, and Pseudomonas aeruginosa) used for the assay of antibacterial activity of polymeric nanoparticles are enumerated in the lab
FTIR spectrums of pectin, cefti1z3o9x0ime, and ceftizoxime-loaded pectin nanocarriers (CPN) wereCdHis3played in Figures 3 and 4
Summary
The oral drug administration route is very common and convenient for drug delivery [1]. Nanotechnology could play a fundamental role as nano-systems have shown their potential as the ideal drug delivery systems for poorly soluble, low absorption and unstable drugs [7] Polymers such as chitosan, gelatin, cellulose, pectin are used to protect drugs from the physiological environment and prolong the release of drugs to improve its stability [8]. Due to its biodegradable and biocompatible nature, this polymer used in pharmaceutical [13,14] and food industries [14,15] Such features make pectin attractive for the preparation of a new and effective drug delivery system for cancer treatment, a combined multiple-cargo system consisting of the hydrophobic drugs [11]. This allows to obtain promising results to be used in medical application in order to control better the drug delivery
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