Abstract

TRANSMISSION is driving the global tuberculosis (TB) epidemic, especially where human immunodeficiency virus (HIV) co-infection is prevalent.1,2 More than half of multidrug-resistant TB cases worldwide occur in persons who have not been treated previously, i.e., as a result of transmission.3 Transmission occurs in the community, of course, but TB is believed to spread most efficiently in congregate settings such as hospitals, clinics, prisons and refugee camps. The wellpublicized transmission of extensively drug-resistant TB (XDR-TB) in rural South Africa, and the six-fold higher risk of multidrug-resistant TB (MDR-TB) reported among hospitalized, adherent, drug-susceptible patients in Tomsk, Siberia, are two compelling examples of hospital transmission of drug-resistant TB in very different parts of the world.4,5

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