Abstract
Background: The exact mechanisms for antipsychotic-induced extrapyramidal side-effects have remained obscure despite intensive research. Previous studies have highlighted a central role for nigral dopamine D2 receptors in the control of motor functions. Aims: The aim of the present study was to examine relationships between dopamine D2 receptor binding in both substantia nigra and temporal cortex with extrapyramidal symptoms among antipsychotic-treated patients with schizophrenia. Methods: Single-photon emission-computed tomography (SPECT) ligand [123I]epidepride was used to determine dopamine D2/3 apparent binding potential in 13 antipsychotic-treated (seven with clozapine, four with olanzapine and two with haloperidol) patients with schizophrenia. Extrapyramidal symptoms were assessed with the Simpson and Angus Scale (SAS). Results: A statistically significant correlation was observed between dopamine D2/3 receptor apparent binding potential in the substantia nigra and extrapyramidal side-effects (r = −0.62, P = 0.024). No correlations were detected in the temporal cortex between dopamine D2/3 receptor binding and extrapyramidal side-effects. Conclusions: These findings support the role of dopamine D2 autoreceptors in substantia nigra regarding drug-induced movement disorders.
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