Abstract
An ethereal extract of omum ( Trachyspermum ammi; Hindustani: ajwan) — a frequently consumed spice — was found to inhibit platelet aggregation induced by arachidonic acid (AA), epinephrine and collagen; in this respect it was most effective against AA-induced aggregation. Inhibition of aggregation by omum could be explained by its effect on platelet thromboxane production as suggested by the following experimental observation. (i) Omum reduced TxB 2 formation in intact platelet preparations from added arachidonate, and (ii) it reduced the formation of TxB 2 from AA-labelled platelets after stimulation with Ca 2+-ionophore A23187 by a direct action on cyclooxygenase as it did not affect the release of AA from labelled platelets. An increased formation of lipoxygenase-derived products from exogenous AA in omum-treated platelets was apparently due to redirection of AA from cyclooxygenase to the lipoxygenase pathway.
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