Abstract
Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for severe respiratory and/or circulatory failure. Few data exist on the potential benefit of ECMO in immunocompromised pediatric patients with cancer and/or hematopoietic cell transplantation (HCT). Over a period of 12 years, eleven (1.9%) of 572 patients with new diagnosis of leukemia/lymphoma and nine (3.5%) of 257 patients post allogeneic HCT underwent ECMO at our center. Five (45%) and two (22%) patients, respectively, survived to hospital discharge with a median event-free survival of 4.2 years. Experiences and outcomes in this cohort may aid clinicians and families when considering ECMO for individual patients.
Highlights
Extracorporeal membrane oxygenation (ECMO) technology can provide temporary life support for children with severe respiratory and/or cardiac failure [1]
Remission status, granulocytopenia and platelet count at ECMO initiation were reported from two large ECMO centers in Europe for nine [7] and twelve [8] patients with hematologic malignancies
During the 12-years study period, 11 of 572 patients with a new diagnosis of leukemia/lymphoma (1.9%; leukemia, 8; lymphoma, 3) and nine of 257 patients post allogeneic hematopoietic cell transplantation (HCT) (3.5%; MDS/ leukemia, 6; non-malignant disorders, 3) underwent ECMO at our center
Summary
Extracorporeal membrane oxygenation (ECMO) technology can provide temporary life support for children with severe respiratory and/or cardiac failure [1]. Detailed oncological characteristics such as interval from diagnosis, ECMO in Children with Cancer/HCT remission status, granulocytopenia and platelet count at ECMO initiation were reported from two large ECMO centers in Europe for nine [7] and twelve [8] patients with hematologic malignancies. Such data may be useful for evaluating patients in the context of decision making for ECMO
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