Extinction of a Conditioned Taste Aversion in Rats: II. Neural Effects in the Nucleus of the Solitary Tract

Abstract

McCaughey, S. A., B. K. Giza, L. J. Nolan and T. R. Scott. Extinction of a conditioned taste aversion in rats: II. Neural effects in the nucleus of the solitary tract. Physiol Behav 61(3) 373–379, 1997.—The formation of a conditioned taste aversion (CTA) in rats results in neural changes at several levels of the gustatory system. In the nucleus of the solitary tract (NTS), the outstanding feature of the response to a CS is a brief burst of activity that is absent in unconditioned animals. The burst occurs about 1 s after stimulus onset and is seen only in neurons that respond well to sugars and the CS (0.0025 M NaSaccharin). We recorded single neuron activity in response to 12 stimuli from taste cells in the NTS of 8 rats, in which a CTA to NaSaccharin had been created and fully extinguished, and in 8 unconditioned controls. The issue was if the neural effects of the CTA in NTS were reversed with extinction. We recorded the activity of 41 neurons in controls and 55 in CTA-extinguished rats. Responses measured across all neurons were not significantly different in spontaneous activity, breadth of tuning, overall response magnitude to each of the 12 stimuli, relationship among stimuli in taste spaces, or time-course. However, cells in the sugar-sensitive subgroup showed a clear vestige of the conditioning experience. They gave a well-defined burst of activity to the CS, though of reduced amplitude and slightly longer latency than in fully conditioned rats. This burst was no longer associated with the conditioned behavior—which was fully extinguished—though it may be a permanent marker for the once-salient CS that can influence subsequent reacquisition of the aversion.