Abstract
(13%).Allofthemhadbeentreatedwithdoses$50Gy(grade2toxicityrate$50Gy:25%,$54Gy:30%).Threepatients(7%) developed grade $2 late toxicity as lymph edema, all of them had been treated with doses $ 50 Gy. 5 pts (11%) developed new desmoids clearly outside the treated region with locally controlled disease until end of f/u after a median time of 16 months (8 - 66), resulting in 5- and 10-year overall PFS rates of 57% and 49%. Patients with previous surgery for desmoids at a different location had a statistically significant increased risk for progression outside the treated area ( p= 0.016). If those patients were excluded from analysis, the 5-year and 10-year overall PFS rates increased to 66% and 56%. Conclusions: EBRT of desmoid tumors after marginal or incomplete resection resulted in long term local control in about two thirds of the patients regardless of resection margin. Dose escalation ($ 45 Gy) resulted in significant improved local control but has to be balanced against increased risks for toxicity. Patients with previous involvement of different regions showed an increased risk of failure outside the treated area.
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