Abstract
We evaluated the frequency distribution of the cytochrome P450 2C19 (CYP2C19) allelic variants in a Korean population and also measured the metabolic ratio of omeprazole, a probe drug for CYP2C19 according to the genotypes. The results were compared with those of other ethnics including Vietnamese data which we had studied. Genotyping of CYP2C19 (*2 and *3) was carried out in 282 Korean subjects using PCR-RFLP and ninety-four subjects were participated in phenotyping study using omeprazole. Plasma concentrations of omeprazole and its metabolite, hydroxy-omeprazole were measured at 2hr after 20mg omeprazole intake. Forty subjects were identified to have CYP2C19 genotype of PM with the frequency of 8.9% CYP2C19*2/*2, 3.9% CYP2C192/*3, and 1.4% CYP2C19*3/*3, while 242 Korean subjects carried extensive metabolizer (EM) genotypes which consists of CYP2C19*1/*1 (41.8%), CYP2C19*1/*2 (35.5%), and CYP2C19*1/*3 (8.5%). The frequency distribution of metabolic ratio was distinctly bimodal. Ten Korean subjects were identified to be PMs with an antimode of 1.2. The frequency (12.6 %) of PM in Korean population is significantly higher than those in Vietnamese (7.1 %) and Thai (6.5), but lower than those in Chinese (19.8 %), Filipinos (22.6 %) and Japanese (18.8%). Clinical Pharmacology & Therapeutics (2004) 75, P69–P69; doi: 10.1016/j.clpt.2003.11.258
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