Abstract
-Alkylidene butenolides bearing a deoxyriboside, a steroid, and a metallocene moiety were synthesized by stereoselective sequential cross-coupling lactonization procedure from the corresponding functionalized terminal alkynes with 3-iodopropenoic acids. The high selectivity of the butenolide ring formation was secured by the Pd/Cu salt ratio. The resulting compounds were tested for antifungal and cytostatic properties. Most notably, γ-alkylidene butenolides bearing deoxyriboside moiety showed promising cytostatic activity in the micromolar range.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.