Abstract
Although the importance of cell adhesion in morphogenesis is already known for quite some time, there are remarkably few studies on the distribution and function of adhesion molecules in tooth development. We have chosen the zebrafish to study the role of specific cell adhesion molecules in the development and renewal of teeth. Zebrafish lack an oral dentition but have pharyngeal teeth which are renewed throughout life. Here we focus on the expression of E (epithelial)-cadherin during the development of the first tooth to develop in the dentition, 'initiator tooth' 4V1. E-cadherin is expressed exclusively in the pharyngeal epithelium and in the enamel organ throughout all stages of development of this first-generation tooth. Further studies are needed to
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