Abstract
The Polycomb group protein Bmi1 is a constituent of the Polycomb repressive complex 1, and it is an important molecule for the regulation of the self-renewal of hematopoietic stem cells. In the field of clinical hematology, there are reports that the level of Bmi1 expression in blast cells is related to the prognosis of acute myeloid leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. We investigated whether the level of Bmi1 expression in leukemic cells is related to the prognosis and the characteristics of childhood acute lymphoblastic leukemia. In all the leukemic blast cells, Bmi1 gene expression was lower value than that in normal B cells. There were no correlations between the level of Bmi1 gene expression in leukemic blast cells and other parameters, including prognosis. Here, we report that the level of Bmi1 expression in blast cells is not related to the prognosis of pediatric acute lymphoblastic leukemia.
Highlights
Mammalian Polycomb group (PcG) protein complexes can be classified into 2 distinct types, Polycomb represssive complex 1 (PRC1) and PRC2
Some reports in the field of clinical hematology have shown that the expression level of Bmi1 in blast cells of acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and myelodysplastic syndrome (MDS) can be related to the prognosis of the disease [8,9,10]
We investigated whether Bmi1 expression is related to the prognosis and cell properties of pediatric acute lymphoblastic leukemia
Summary
Mammalian Polycomb group (PcG) protein complexes can be classified into 2 distinct types, Polycomb represssive complex 1 (PRC1) and PRC2. Some reports in the field of clinical hematology have shown that the expression level of Bmi in blast cells of acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and myelodysplastic syndrome (MDS) can be related to the prognosis of the disease [8,9,10]. According to these reports, leukemia cells that have a high Bmi expression are correlated with poor prognosis. We investigated whether Bmi expression is related to the prognosis and cell properties of pediatric acute lymphoblastic leukemia
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