Abstract
The present study was designed to investigate changes of opioid receptor like 1 receptor (ORL 1, NOP) mRNA expression in some pain-related brain nuclei of neuropathic pain rats using in situ hybridization technique. Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of ORL 1, plays an important role in neuropathic pain through its receptor. There are ORL 1 mRNA expression in the nucleus of raphe magnus (NRM), ventrolateral periaqueductal gray (vlPAG) and dorsal raphe nucleus (DRN) of rat mesencephalon. In the sciatic nerve chronic constriction injury (CCI)-induced neuropathic pain model, a significant increase of ORL 1 mRNA expression was observed in these three regions on the 7th day after operation, and the changes lasted for 2 weeks. The result indicated that ORL 1 synthesis was increased in NRM, vlPAG and DRN of neuropathic pain rats, suggesting that ORL 1 was involved in nociceptive transmission of neuropathic pain.
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