Abstract
In this study, we investigated the expression of Ki-67, p53, and VEGF in Wilms tumor and the relationship with clinical and histopathologic findings. The expression of the markers was evaluated with immunohistochemistry methods on samples obtained from surgical resection in 30 patients diagnosed with Wilms tumor. Pathologic examination of resected specimens showed: triphasic mixed-type nephroblastoma (53.3%), monophasic blastemal (30.0%), monophasic epithelial (13.3%), and focal anaplastic (3.3%). The mean proliferation index according to different stages of the tumor was: stage I (1.41%±2.06), stage II (10.91% ± 18.96), stage III (15.00% ±21.21), stage IV (45.00% ± 25.98), stage V (0) ( p = 0.003). P53, and VEGF expression were not associated with tumor stage ( p = 0.59, and 0.85, respectively), and unfavorable histology. Ki-67 expression in Wilms tumor is strongly associated with higher tumor stages. Further investigation of the role of Ki-67 along with other prognostic factors, to build a multivariate model to determine the prognosis, is recommended.
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