Abstract
Background: Members of the IGF-family regulate growth and development. IGF-II is a growth factor for HCC. Its expression, as detected by Northern analysis, is enhanced in cirrhotic nodules close to HCC. Methods: We studied the expression pattern of IGF-II RNA on 8 cirrhotic livers \HBV: n=4; HCV: n=3; alcoholic: n=2), using a double-labeled [3 S]-UTP/GTP riboprobe for IGF-II RNA. This was combined with immunostaining for the IGF-IIR (mab 2C2). Results: IGF-II RNA was expressed homogeneously over all hepatocytes of regenerative nodules, with weak signals over mesenchymal cells and no signal over bile duct epithelia. IGFIIR was found over all hepatocytes, but prominent over periportal hepatocytes in lobular zone I. Conclusions: Since comparable levels of IGF-II RNA are expressed over all hepatocytes and the IGF-IIR protein predominates on periportal hepatocytes, autoand paracrine stimulation of neoplastic growth in preneoplastic lesions of HCC appears to be mediated by an upregulated IGF-IIR. ENDbSCOPlC AND ULTRASOUND CRITERIA PREDICTING LESS DEVELOPMENT OF PORTALHYPERTENSIVE GASTROPATHY IN HEPATIC CIRRHOSIS C. Gheorahe. L. Gheorahe, S. Griaoruta, A. ODroiu, Center of Gastroenterology Fundeni Hospital, Bucharest, Romania
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