Abstract
The synovial membrane in rheumatoid arthritis (RA) contains large lymphocytic infiltrates, sometimes organized in germinal-like centres. The presence of plasma cells within the synovium and the production of clonally related immunoglobulin transcripts have been observed. The exact nature of clonal expansion and its role in generation of specific, mutated antibodies in RA is not known. Somatic mutations and isotype switching in synovial B lymphocytes might suggest the antigen-driven process. This would be supported by the expression of recombination-activating genes 1 and 2 (Rag1 and Rag2).
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