Abstract
Objective To investigate the expression of HIF-1α and Snail proteins in rectal cancer and their significance in metastasis and prognosis.Methods The expression of HIF-1α and Snail proteins was detected by using immunohistochemical SABC method in 121 cases of rectal cancer tissues.Results The positive rates of HIF-1α and Snail in rectal cancer were 58.7%(71/121) and 71.9%(87/121),respectively the expression of HIF-1α and Snail were significantly related with the lymph node metastasis and TNM stage of rectal cancer(P0.05).HIF-1α expression have significantly positive correlation with Snail expression(P0.05).Conclusion The overexpression of HIF-1α and Snail might be important biological marker for invasion and metastasis and prognosis of rectal carcinoma.
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