Abstract
Objective To study the human telomerase reverse transcriptase (hTERT) mRNA in peripheral blood of patients with gallbladder carcinoma and its clinical significance.Methods Fifty cases of gallbladder cancer (GBC group),50 cases of adenomatous polyps (AMP group) and 50 normal volunteers (control group) were selected.The expression of hTERT mRNA in peripheral blood was detected by using real-time fluorescent quantitative polymerase chain reaction (FQ-PCR).Results The positive rate of hTERT mRNA in GBC group (66％) was significantly higher than in AMP group (14％) (P ＜ 0.05),and that in AMP group was higher than in control group (P ＜ 0.05).There was significant difference in the hTERT mRNA expression between T3 + T4 and T1 + T2 or between negative and positive lymph nodes (P ＜ 0.05).Conclusion The hTERT mRNA expression in peripheral blood of GBC was significantly increased,and associated with depth of invasion and lymph node metastasis. Key words: Gallbladder; Human telomerase reverse transcriptase; Polymerase chain reaction
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
