Abstract
Tissue destruction of the lacrimal and salivary glands is the cardinal feature of Sjögren’s syndrome. Although lymphocyte infiltration accompanies this destruction, the mechanism of tissue destruction has not been elucidated. Recently, it was suggested that granzyme A and perforin are associated with immune-mediated cytolysis in such autoimmune diseases as rheumatoid arthritis, where the up-regulation of these compounds in synovial fluid lymphocytes causes tissue destruction.1 We have investigated whether granzyme A and perforin are associated with Sjögren’s syndrome.
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