Abstract
The level of FcγR on peripheral blood mononuclear cells (PBMC) was determined by ABC-ELISA in 43 patients with primary hepatocellular carcinoma (PHC) and in 8 patients with space-occupying benign lesion (BL) in liver, twelve patients who received carcinomaectomy were followed up to detect their FcγR. Nine PBMC samples from PHC were treated with rlFNγ. The results showed that; 1. the level of FcγR in PHC patients was significantly lower than that in BL and in normal control; 2. the expression of FcγR was enhanced in postoperated PHC patients; and 3. the production of IFNγ in PHC patients was defective. The level of FcγR on PBMC was increased obviously in PHC after PBMC being treated with rlFNγ but was still lower than that in control. These results suggested; (1) FcγR detection is helpful for distinguishing malignant liver lesion from benign ; (2) the inhibited expression of FcγR in PHC could be related to some factors secreted by cancer tissues and also to low level of IFNγ; and (3) IFNγ stimulates the expression of FcγRin vitro as one of the anti-tumor mechanism for IFNγ.
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