Abstract
Objective To examine the expression levels of fatty acid 2-hydroxylase (FA2H) mRNA in papillary thyroid cancer (PTC) tissue samples and evaluate the relationship between FA2H and the clinicopathological characteristics and overall survival (OS) in PTC. Methods Real-time quantitative polymerase chain reaction (Real-time PCR) was used to detected the expression levels of FAH2 in PTC and normal samples. The correlation between FA2H and the clinicopathological features in PTC was analyzed. Online Kaplan-Meier database was used to explore the effects of FA2H on survival of PTC patients. Results The FA2H levels were higher in PTC cancer tissues than those in normal tissues in PTC (3.86±0.27 vs. 1.00±0.16, t=10.033, P<0.01). FA2H levels were correlated to T stage, N stage and TNM positively (χ2=5.570, 6.169 and 6.508, P<0.05). OS rate of PTC patients with higher levels of FA2H were shorter than those with higher levels of FA2H expression (P<0.05). Conclusion FA2H was upregulated in PTC cancer tissues, and related to tumor size, lymph node metastasis and TNM stage positively. Increased expression of FA2H is related to shorter OS in PTC. Key words: Papillary thyroid cancer; Fatty acid 2-hydroxylase
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