Abstract

Expression of macrophage sialoadhesin and erythroblast receptors involved into the hemopoietic islet formation is studied in cyclophosphamide-treated CBA mice. The number of hemopoietic islets and the content of immature granulocytic and erythroid cells were determined. Cyclophosphane reduces the expression of sialoadhesin and erythroblast receptors. It can be hypothesized that the disturbances in granulocyte differentiation result from impaired sialoadhesin-mediated interaction between hemopoietic cells and macrophages.

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