Expression of anglopoietin-2 in patients with diabetes nephropathy and correlation study between anglopoietin-2 and proteinuria

Abstract

[Objective]To investigate the correlation between proteinuria and anglopoietin-2(Ang-2)in patients with diabetes nephropathy.[Methods] The clinical data of 104 patients with diabetes nephropathy were analyzed retrospectively.All the patients were divided into non-pmteinuria group with 45 cases and proteinuria group with 59 cases according to the urinary albumin excretion rate(UAER).UAER was detected by radioimmunoassay.The level of serum Ang-2 was detected by double antibody enzyme linked immunosorbent assay.Blood pressure,glycosylated hemoglobin(HbA:c),fasting blood glucose(FBG),treacylglycerol(TG),total cholesterol(TC),creatinine(Cr),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)were also detected.[Results]There was no significant difference in diastolic blood pressure,FBG,HbA1c,TG,TC,LDL-C,HDL-C between two groups(P＞0.05).Systolic blood pressure and Cr in proteinuria group[(140.1±17.4)mm Hg(1 mm Hg=0.133 kPa),(126.7±23.8)μmol/L]had statistical significance compared with those in non-proteinuria group[(126.3 ± 15.2)mm Hg,(70.3 ± 22.1)μ mol/L](P ＜ 0.05).The level of serum Ang-2 in proteinuria group was significantly higher than that in non-proteinuria group[(24.86±4.31)ng/L vs.(18.83±7.28)ng/L](P＜0.01).Partial correlation analysis showed that UAER was positively correlated with Ang-2(r=0.615,P＜0.01).[Conclusions] The level of serum Ang-2 increases significantly when there is renal damage in patients with diabetes nephropathy. Key words: Diabetic nephropathies; Proteinuria; Anglopoietin-2; Relative