Expression and significance of serum insulin-like growth factor-1 in patients with obstructive sleep apnea hypopnea syndrome

Abstract

Objective:To investigate the expression and significance of serum insulinlike growth factor-1(IGF-1) in adult patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Method:One hundred and seven patients of OSAHS diagnosed with PSG were included in the observation group，which were divided into heavy, medium and light group according to AHI.Fifty case of healthy people without OSAHS were included in control group.Serum IGF-1 were measured by ELISA. Thirty patients of heavy OSAHS received surgery and CPAP treatment for three months,and were retested the levels of IGF-1 and PSG six months later.Result:①With the increase of OSAHS severity, the levels of serum IGF-1 were gradually decreased (F=37.732,P<0.01). There was no significant difference between mild group and healthy people (P>0.05), while there was significant differences between the remaining groups (P<0.01). ②Serum IGF-1 level has no correlation with BMI and age in OSAHS patients(P>0.05), and negatively correlated with LSaO₂,and positively correlated with AHI (P<0.01). ③Serum IGF-1 level［(46.56±3.74)μg/L］ increased slightly compared with those before treatment［(42.79±4.87）μg/L］ in 30 severe patients after treatment with 3 months CPAP and regimen (P<0.01). Serum IGF-1 level［(56.61±5.46)μg/L］ increased significantly after treatment for six months; AHI level (18.72±7.36) was significantly lower than that before treatment (48.77±10.51), and LSaO₂［(87.42±8.61)%］ increased significantly than that before treatment［(68.33±10.24)%］.Conclusion:OSAHS patients with decreased serum IGF-1 level may be associated with concurrent insulin resistance. Surgery combined with more than half a year of CPAP treatment can significantly reduce AHI, improve the level of LSaO₂ and serum IGF-1. Serum IGF-1 levels could be used as a monitor of efficacy evaluation.