Abstract

Objective To explore the condition of MYC/BCL2 protein coexpression in 245 patients with diffuse large B-cell lymphoma （DLBCL）and to find the correlations among MYC/BCL2 protein coexpres-sion,the germinal center B-cell-like （GCB）subtype and non-GCB subtype.Methods Paraffin-embedded lymphoma samples from 245 patients with DLBCL were studied using immunohistochemistry for MYC,BCL2, CD10,BCL6,MUM1 and KI67.And the protein expressions of them were analyzed.Results In the speci-mens of 245 patients with DLBCL,the patients with non-GCB were 163 （66.5%）,and the patients with GCB were 82 （33.5%）.The group of MYC/BCL2 protein coexpression comprised 35.9% （88/246）of the all patients.Non-GCB subtype group had a significantly higher frequency of MYC/BCL2 protein coexpression than the GCB subtype group （41.7%∶24.4%;χ2 =7.116,P=0.008）.Conclusion The data shows that MYC/BCL2 protein coexpression occurs significantly more commonly in the non-GCB subtype.We can predict prog-nosis and choose therapeutic regimen base on the assessment for MYC and BCL2 protein expression. Key words: Lymphoma, large B-cell, diffuse ; Proto-oncogene proteins c-myc ; BCL2 protein

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