Abstract

Objective To investigate the expression of mTOR in leukemia.Methods Real-time quantitative PCR was used to investigate the expression of mTOR in leukemia.Results The mRNA expression of mTOR in newly diagnosed leukemia and recurrent patients was higher than that in normal control and patients who had complete response.Patients who have not achieved complete hematological response(CR)after induction therapy,the mRNA level of mTOR was higher than that in normal controol.There was no statistical significance between newly diagnosed group and relapsed group.Conclusion Higher levels of mTOR mRNA expression was closely related to leukemia. Key words: Leukemia; Gene mTOR; Realtime quantitative PCR

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