Abstract
Objective To investigate the expression of miR-31 in rectal cancer(RC) and its relationship with clinicopathological indexes in patients with rectal cancer.Methods The expressions of miR-31 in 81 cases of RC and the corresponding normal mucosa were detected by RT-PCR,and its relationships with clinicopathological indexes including TNM stage,vascular invasion were analyzed.Results The expression level of miR-31 was elevated in rectal cancer,which was 16.18 times as the normal mucosa (P =0.001).The expression of miR-31 was positively correlated with TNM stage and tumor local invasion.The expression level of miR-31 was higher in tumor with stage TNM Ⅲ + Ⅳ than that in tumor with stage TNM Ⅰ + Ⅱ (P =0.044),and the expression level of miR-31 was higher in tumor through the visceral peritoneum than that in tumor with direct invasion of other organs and structures (T4) than that in tumor confined to the intramural tissue (T1 + T2 + T3) (P =0.043).Conclusions The expression of miR-31 is high in rectal cancer,and is positively correlated with TNM stage and tumor local invasion,indicating that miR-31 overexpression is involved in the development and progression of rectal cancer,and can be the potential diagnostic marker and therapeutic target of rectal cancer. Key words: miR-31; Rectal cancer; TNM stage; Reverse transcriptase polymerase chain reaction
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